A large body of evidence
shows that spinal circuits are significantly affected by training, and that
intrinsic circuits that drive locomotor tasks are located in lumbosacral spinal
segments in rats with complete spinal cord transection.
However, after
incomplete lesions, the effect of treadmill training has been debated, which is
likely because of the difficulty of separating spontaneous stepping from
specific training-induced effects.
According
to a study published in Neural
Regeneration Research (Vol.
8, No. 27, 2013), a rat model of spinal cord contusion at the T10 level was
used to examine the effect of step training. After 3 weeks of step training,
the rats with spinal cord contusion at the T10 level exhibited a significantly
greater improvement in the Basso, Beattie and Bresnahan score.
The expression of
growth-associated protein-43 in the spinal cord lesion site and the number of
tyrosine hydroxylase-positive ventral neurons in the second lumbar spinal
segment were greater at 11 weeks post-injury, while the levels of brain-derived
neurotrophic factor protein in the spinal cord lesion site showed no changes.
These results suggest
that treadmill training substantially improved spontaneous motor activity in
rats with incomplete spinal cord injury.
The
improvement in rat behavior was associated with a significant increase in
growth-associated protein-43 expression in the injured spinal cord and in
tyrosine hydroxylase expression in the second lumbar spinal segment. Treadmill
training significantly improves functional recovery and neural plasticity after
incomplete spinal cord injury.source: Medicalnewstoday
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